Mathematical Modeling of Multilayered Skin with Embedded Tumor Through Combining Laser Ablation and Nanoparticles: Effects of Laser Beam Area, Wavelength, Intensity, Tumor Absorption Coefficient and Its Position

Laser ablation is gaining acceptance as a cancer treatment technique because of its localized energy delivery to the tumorous tissue. The combination laser with nanoparticles allows for more precise targeting ablative area less damage adjacent healthy Nevertheless, heat tissue still potential concern. Therefore, mathematical modeling laser-tissue interactions necessary part clinical planning. In this study, temperature distribution during laser-induced thermotherapy in investigates using multilayered skin (epidermis, dermis, subcutaneous fat, and muscle) an embedded tumor model. effects related parameters systematically investigate; wavelength, intensity, beam area, absorption coefficient, position, blood perfusion rate, irradiation time. Mathematical study solved by finite element method (FEM) via COMSOLTM Multiphysics Software. thermal phenomena are described Beer-Lambert’s law Pennes’s bioheat equation.